Rigidity and flexibility of biological networks

Abstract

The network approach became a widely used tool to understand the behaviour of complex systems in the last decade. We start from a short description of structural rigidity theory. A detailed account on the combinatorial rigidity analysis of protein structures, as well as local flexibility measures of proteins and their applications in explaining allostery and thermostability is given. We also briefly discuss the network aspects of cytoskeletal tensegrity. Finally, we show the importance of the balance between functional flexibility and rigidity in protein-protein interaction, metabolic, gene regulatory and neuronal networks. Our summary raises the possibility that the concepts of flexibility and rigidity can be generalized to all networks.

21 pages, 4 figures, 1 table

References in corpus (9)

• CFinder: Locating cliques and overlapping modules in biological networks
• Induced fit, conformational selection and independent dynamic segments: an extended view of binding events
• Creative elements: network-based predictions of active centres in proteins, cellular and social networks
• Effective medium theory of semiflexible filamentous networks
• Discrete breathers in protein structures
• Long-range energy transfer in proteins
• Microrheological Characterisation of Anisotropic Materials
• Sensitivity of protein rigidity analysis to small structural variations: a large-scale comparative analysis
• Tensegrity and Motor-Driven Effective Interactions in a Model Cytoskeleton