Stochastic sensing of polynucleotides using patterned nanopores
arXiv:1201.4489 · doi:10.1103/PhysRevX.2.021002
Abstract
The effect of the microscopic structure of a pore on polymer translocation is studied using Langevin dynamics simulation, and the consequence of introducing patterned stickiness inside the pore is investigated. It is found that the translocation process is extremely sensitive to the detailed structure of such patterns with faster than exponential dependence of translocation times on the stickiness of the pore. The stochastic nature of the translocation process leads to discernable differences between how polymers with different sequences go through specifically patterned pores. This notion is utilized to propose a stochastic sensing protocol for polynucleotides, and it is demonstrated that the method, which would be significantly faster than the existing methods, could be made arbitrarily robust.
10 pages, 12 figures
References in corpus (8)
- Physical approaches to DNA sequencing and detection
- Influence of polymer-pore interactions on translocation
- Sequence dependence of DNA translocation through a nanopore
- Langevin Dynamics Simulations of Polymer Translocation through Nanopores
- Polymer Translocation in Crowded Environments
- Active polymer translocation through flickering pores
- Translocation Dynamics with Attractive Nanopore-Polymer Interactions
- Dynamics of DNA translocation through an attractive nanopore
Cited by in corpus (13)
- Theory of pore-driven and end-pulled polymer translocation dynamics through a nanopore: An overview
- Theory of polymer translocation through a flickering nanopore under an alternating driving force
- Role of Non-Equilibrium Conformations on Driven Polymer Translocation
- Directed translocation of a flexible polymer through a cone-shaped channel
- Translocation through environments with time dependent mobility
- Sequencing of semiflexible polymers of varying bending rigidity using patterned pores
- Current fluctuations across a nanopore
- Active translocation of a semiflexible polymer assisted by an ATP-based molecular motor
- Pulling a DNA molecule through a nanopore embedded in an anionic membrane: tension propagation coupled to electrostatics
- Translocation of short and long polymers through an interacting pore
- Chaperone driven polymer translocation through Nanopore: spatial distribution and binding energy
- Force spectroscopy analysis in polymer translocation
- Non-equilibrium effects in chaperone-assisted translocation of a stiff polymer