paper

Cancer Networks: A general theoretical and computational framework for understanding cancer

arXiv:1110.5865

Abstract

We present a general computational theory of cancer and its developmental dynamics. The theory is based on a theory of the architecture and function of developmental control networks which guide the formation of multicellular organisms. Cancer networks are special cases of developmental control networks. Cancer results from transformations of normal developmental networks. Our theory generates a natural classification of all possible cancers based on their network architecture. Each cancer network has a unique topology and semantics and developmental dynamics that result in distinct clinical tumor phenotypes. We apply this new theory with a series of proof of concept cases for all the basic cancer types. These cases have been computationally modeled, their behavior simulated and mathematically described using a multicellular systems biology approach. There are fascinating correspondences between the dynamic developmental phenotype of computationally modeled {\em in silico} cancers and natural {\em in vivo} cancers. The theory lays the foundation for a new research paradigm for understanding and investigating cancer. The theory of cancer networks implies that new diagnostic methods and new treatments to cure cancer will become possible.

Key words: Cancer networks, cene, cenome, developmental control networks, stem cells, stem cell networks, cancer stem cells, stochastic stem cell networks, metastases hierarchy, linear networks, exponential networks, geometric cancer networks, cell signaling, cancer cell communication networks, systems biology, computational biology, multiagent systems, muticellular modeling, cancer modeling

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