Modular Random Boolean Networks

Abstract

Random Boolean networks (RBNs) have been a popular model of genetic regulatory networks for more than four decades. However, most RBN studies have been made with random topologies, while real regulatory networks have been found to be modular. In this work, we extend classical RBNs to define modular RBNs. Statistical experiments and analytical results show that modularity has a strong effect on the properties of RBNs. In particular, modular RBNs have more attractors and are closer to criticality when chaotic dynamics would be expected, compared to classical RBNs.

33 pages, 14 figures, 11 tables. Corrected version, added experiments with large networks confirming results. Accepted in Artificial Life

References in corpus (2)

• Genetic networks with canalyzing Boolean rules are always stable
• Degeneracy: a design principle for achieving robustness and evolvability

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