Continuum Electromechanical Modeling of Protein-Membrane Interaction

Abstract

A continuum electromechanical model is proposed to describe the membrane curvature induced by electrostatic interactions in a solvated protein-membrane system. The model couples the macroscopic strain energy of membrane and the electrostatic solvation energy of the system, and equilibrium membrane deformation is obtained by minimizing the electro-elastic energy functional with respect to the dielectric interface. The model is illustrated with the systems with increasing geometry complexity and captures the sensitivity of membrane curvature to the permanent and mobile charge distributions.

5 pages, 12 figures

References in corpus (1)

• Membrane-protein interactions in mechanosensitive channels

Cited by in corpus (5)

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• Fast Algorithm for Simulating Lipid Vesicle Deformation I: Spherical Harmonic Approximation
• Electrostatic forces on charged surfaces of bilayer lipid membranes