Studies of reversible capsid shell growth

Abstract

Results from molecular dynamics simulations of simple, structured particles capable of self-assembling into polyhedral shells are described. The analysis focuses on the growth histories of individual shells in the presence of an explicit solvent and the nature of the events along their growth pathways; the results provide further evidence of the importance of reversibility in the assembly process. The underlying goal of this approach is the modeling of virus capsid growth, a phenomenon at the submicroscopic scale that, despite its importance, is little understood.

11 pages, 8 figures

References in corpus (4)

• Virus shapes and buckling transitions in spherical shells
• Reversible self-assembly of patchy particles into monodisperse icosahedral clusters
• Role of reversibility in viral capsid growth: A paradigm for self-assembly
• Stochastic kinetics of viral capsid assembly based on detailed protein structures

Cited by in corpus (6)

• Stochastic dynamics of virus capsid formation: direct versus hierarchical self-assembly
• Molecular dynamics simulation of reversibly self-assembling shells in solution using trapezoidal particles
• Modeling capsid self-assembly: Design and analysis
• Self-assembly of artificial microtubules
• Hierarchical assembly is more robust than egalitarian assembly in synthetic capsids
• Simulations of HIV capsid protein dimerization reveal the effect of chemistry and topography on the mechanism of hydrophobic protein association