Two-state flashing molecular pump

Abstract

Here we study a pumping device capable of maintaining a density gradient and a flux of particles across a membrane. Its driving mechanism is based on the flashing ratchet effect powered by the random telegraph process in the presence of thermal fluctuations. Unlike Brownian motors, the concentrations at both reservoir boundaries need to be implemented as boundary conditions. The residence transition rates of the dichotomic flashing are related to the binding and hydrolysis of ATP molecules. The model is exactly solved and explored. The pump energetics is discussed and the relevant parameter values are tuned within a biological scale.

6 pages, 6 figures

References in corpus (2)

• Efficiency of molecular motors at maximum power
• Fluctuation-Driven Molecular Transport in an Asymmetric Membrane Channel

Cited by in corpus (4)

• Translocation of a polymer chain driven by a dichotomous noise
• Michaelis-Menten dynamics of a polymer chain out of a dichotomous ATP-based motor
• Ambipolar Ion Pumping with Ratchet Driven Active Membranes
• Brownian diode: Molecular motor based on a semi-permeable Brownian particle with internal potential drop