Stability of limit cycles in a pluripotent stem cell dynamics model

Abstract

This paper is devoted to the study of the stability of limit cycles of a nonlinear delay differential equation with a distributed delay. The equation arises from a model of population dynamics describing the evolution of a pluripotent stem cells population. We study the local asymptotic stability of the unique nontrivial equilibrium of the delay equation and we show that its stability can be lost through a Hopf bifurcation. We then investigate the stability of the limit cycles yielded by the bifurcation using the normal form theory and the center manifold theorem. We illustrate our results with some numerics.

References in corpus (2)

• A mathematical study of the hematopoiesis process with applications to chronic myelogenous leukemia
• Stability and Hopf bifurcation in a mathematical model of pluripotent stem cell dynamics

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