Hyperpolarized Long-T1 Silicon Nanoparticles for Magnetic Resonance Imaging

Abstract

Silicon nanoparticles are experimentally investigated as a potential hyperpolarized, targetable MRI imaging agent. Nuclear T_1 times at room temperature for a variety of Si nanoparticles are found to be remarkably long (10^2 to 10^4 s) - roughly consistent with predictions of a core-shell diffusion model - allowing them to be transported, administered and imaged on practical time scales without significant loss of polarization. We also report surface functionalization of Si nanoparticles, comparable to approaches used in other biologically targeted nanoparticle systems.

supporting material here: http://marcuslab.harvard.edu/Aptekar_hyper1_sup.pdf

References in corpus (3)

• Coherence Time of a Solid-State Nuclear Qubit
• Dynamic Nuclear Polarization in Silicon Microparticles
• The Intrinsic Origin of Spin Echoes in Dipolar Solids Generated by Strong Pi Pulses

Cited by in corpus (11)

• In-vivo magnetic resonance imaging of hyperpolarized silicon particles
• Synthesis of Long-T1 Silicon Nanoparticles for Hyperpolarized 29Si Magnetic Resonance Imaging
• Optical hyperpolarization of 13C nuclear spins in nanodiamond ensembles
• Radical-free dynamic nuclear polarization using electronic defects in silicon
• Large Room Temperature Bulk DNP of ${}^{13}$C via P1 Centers in Diamond
• Decay of nuclear hyperpolarization in silicon microparticles
• Two-electron-spin ratchets as a platform for microwave-free dynamic nuclear polarization of arbitrary material targets
• High temperature annealing enhanced diamond 13C hyperpolarization at room temperature
• Chemisorption of water on the surface of silicon microparticles measured by DNP-enhanced NMR
• DNP-NMR of surface hydrogen on silicon microparticles
• Controlled synthesis and characterization of porous silicon nanoparticles for dynamic nuclear polarization