Work distribution in manipulated single biomolecules
arXiv:0901.2666 · doi:10.1088/1478-3975/6/2/025011
Abstract
We consider the relation between the microscopic and effective descriptions of the unfolding experiment on a model polypeptide. We evaluate the probability distribution function of the performed work by Monte Carlo simulations and compare it with that obtained by evaluating the work distribution generating function on an effective Brownian motion model tailored to reproduce exactly the equilibrium properties. The agreement is satisfactory for fast protocols, but deteriorates for slower ones, hinting at the existence of processes on several time scales even in such a simple system.
To appear in Physical Biology, Special issue: Polymer physics of the cell
References in corpus (8)
- Experimental Free Energy Surface Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality
- An Ising-Like model for protein mechanical unfolding
- Work probability distribution in systems driven out of equilibrium
- Mechanical unfolding and refolding pathways of ubiquitin
- Reconstructing the free energy landscape of a polyprotein by single-molecule experiments
- Work distribution and path integrals in general mean-field systems
- Work probability distribution in single molecule experiments
- Protein mechanical unfolding: a model with binary variables