Group theory of icosahedral virus capsids: a dynamical top-down approach
arXiv:0806.1029 · doi:10.1016/j.jtbi.2008.10.019
Abstract
We explore the use of a top-down approach to analyse the dynamics of icosahedral virus capsids and complement the information obtained from bottom-up studies of viral vibrations available in the literature. A normal mode analysis based on protein association energies is used to study the frequency spectrum, in which we reveal a universal plateau of low-frequency modes shared by a large class of Caspar-Klug capsids. These modes break icosahedral symmetry and are potentially relevant to the genome release mechanism. We comment on the role of viral tiling theory in such dynamical considerations.
35 pages, many figures, animations available at http://biomaths.org
References in corpus (5)
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