A microstructurally informed model for the mechanical response of three-dimensional actin networks

Abstract

We propose a class of microstructurally informed models for the linear elastic mechanical behavior of cross-linked polymer networks such as the actin cytoskeleton. Salient features of the models include the possibility to represent anisotropic mechanical behavior resulting from anisotropic filament distributions, and a power-law scaling of the mechanical properties with the filament density. Mechanical models within the class are parameterized by seven different constants. We demonstrate a procedure for determining these constants using finite element models of three-dimensional actin networks. Actin filaments and cross-links were modeled as elastic rods, and the networks were constructed at physiological volume fractions and at the scale of an image voxel. We show the performance of the model in estimating the mechanical behavior of the networks over a wide range of filament densities and degrees of anisotropy.

26 pages, 9 figures

References in corpus (10)

• Elasticity of Semiflexible Biopolymer Networks
• The origin of stiffening in cross-linked semiflexible networks
• Elasticity of Stiff Polymer Networks
• Deformation of crosslinked semiflexible polymer networks
• Distinct regimes of elastic response and deformation modes of cross-linked cytoskeletal and semiflexible polymer networks
• Nonaffine Correlations in Random Elastic Media
• Floppy modes and non-affine deformations in random fiber networks
• Stiff Polymers, Foams and Fiber Networks
• The mechanical response of semiflexible networks to localized perturbations
• The Role of Architecture in the Elastic Response of Semiflexible Polymer and Fiber Networks