Point Mutations Effects on Charge Transport Properties of the Tumor-Suppressor Gene p53

Abstract

We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective single-strand or double-strand tight-binding models which simulate hole propagation along the DNA, a statistical analysis of charge transmission modulations associated with all possible point mutations is performed. We find that in contrast to non-cancerous mutations, mutation hotspots tend to result in significantly weaker {\em changes of transmission properties}. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.

arXiv comment4.1 PR style pages with 5 figures included

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• Electronic localization at mesoscopic length scales: different definitions of localization and contact effects in a heuristic DNA model
• Influence of transition mutations and disorder on charge localization and transfer along B-DNA sequences