An accurate model for genetic hitch-hiking

Abstract

We suggest a simple deterministic approximation for the growth of the favoured-allele frequency during a selective sweep. Using this approximation we introduce an accurate model for genetic hitch-hiking. Only when Ns < 10 (N is the population size and s denotes the selection coefficient), are discrepancies between our approximation and direct numerical simulations of a Moran model noticeable. Our model describes the gene genealogies of a contiguous segment of neutral loci close to the selected one, and it does not assume that the selective sweep happens instantaneously. This enables us to compute SNP distributions on the neutral segment without bias.

12 pages, 10 figures

Cited by in corpus (5)

• Linkage disequilibrium under recurrent bottlenecks
• Fixation of a Deleterious Allele under Mutation Pressure and Finite Selection Intensity
• Sequential Markov coalescent algorithms for population models with demographic structure
• The pattern of genetic hitchhiking under recurrent mutation
• An Eco-Evolutionary approach of Adaptation and Recombination in a large population of varying size