259 citations
4 papers
Self-sustained asynchronous irregular states and Up/Down states in thalamic, cortical and thalamocortical networks of nonlinear integrate-and-fire neurons
Alain Destexhe
Randomly-connected networks of integrate-and-fire (IF) neurons are known to display asynchronous irregular (AI) activity states, which resemble the discharge activity recorded in t…
Extracting synaptic conductances from single membrane potential traces
Martin Pospischil, Zuzanna Piwkowska, Thierry Bal +1
In awake animals, the activity of the cerebral cortex is highly complex, with neurons firing irregularly with apparent Poisson statistics. One way to characterize this complexity i…
Characterizing synaptic conductance fluctuations in cortical neurons and their influence on spike generation
Zuzanna Piwkowska, Martin Pospischil, Romain Brette +4
Cortical neurons are subject to sustained and irregular synaptic activity which causes important fluctuations of the membrane potential (Vm). We review here different methods to ch…
Calculating event-triggered average synaptic conductances from the membrane potential
Martin Pospischil, Zuzanna Piwkowska, Michelle Rudolph +2
The optimal patterns of synaptic conductances for spike generation in central neurons is a subject of considerable interest. Ideally, such conductance time courses should be extrac…