1.8k citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- National Institutes of HealthUS4 papers
- Research Triangle Park FoundationUS3 papers
- Los Alamos National LaboratoryUS2 papers
- Oak Ridge National LaboratoryUS2 papers
- Argonne National LaboratoryUS1 paper
- Brigham and Women's HospitalUS1 paper
- Columbia UniversityUS1 paper
- Duke UniversityUS1 paper
- Enveda Therapeutics (United States)US1 paper
- Environmental Protection AgencyUS1 paper
- George Washington UniversityUS1 paper
- Georgia Institute of TechnologyUS1 paper
11 papers
Functional Analysis of Variance for Association Studies
Olga A. Vsevolozhskaya, Dmitri V. Zaykin, Mark C. Greenwood +2
While progress has been made in identifying common genetic variants associated with human diseases, for most of common complex diseases, the identified genetic variants only accoun…
Decoding the Molecular Universe -- Workshop Report
Thomas O. Metz, Joshua N. Adkins, Peter B. Armentrout +30
On August 9-10, 2023, a workshop was convened at the Pacific Northwest National Laboratory (PNNL) in Richland, WA that brought together a group of internationally recognized expert…
Fast increased fidelity approximate Gibbs samplers for Bayesian Gaussian process regression
Kelly R. Moran, Matthew W. Wheeler
The use of Gaussian processes (GPs) is supported by efficient sampling algorithms, a rich methodological literature, and strong theoretical grounding. However, due to their prohibi…
A Hierarchical Integrative Group LASSO (HiGLASSO) Framework for Analyzing Environmental Mixtures
Jonathan Boss, Alexander Rix, Yin-Hsiu Chen +6
Environmental health studies are increasingly measuring multiple pollutants to characterize the joint health effects attributable to exposure mixtures. However, the underlying dose…
Bayesian joint modeling of chemical structure and dose response curves
Kelly R. Moran, David Dunson, Matthew W. Wheeler +1
Today there are approximately 85,000 chemicals regulated under the Toxic Substances Control Act, with around 2,000 new chemicals introduced each year. It is impossible to screen al…
DOT: Gene-set analysis by combining decorrelated association statistics
Olga A Vsevolozhskaya, Min Shi, Fengjiao Hu +1
Historically, the majority of statistical association methods have been designed assuming availability of SNP-level information. However, modern genetic and sequencing data present…
A quantile-based g-computation approach to addressing the effects of exposure mixtures
Alexander P. Keil, Jessie P. Buckley, Katie M. OBrien +3
Exposure mixtures frequently occur in data across many domains, particularly in the fields of environmental and nutritional epidemiology. Various strategies have arisen to answer q…
Unsupervised Identification of Study Descriptors in Toxicology Research: An Experimental Study
Drahomira Herrmannova, Steven R. Young, Robert M. Patton +3
Identifying and extracting data elements such as study descriptors in publication full texts is a critical yet manual and labor-intensive step required in a number of tasks. In thi…
Robust Tests in Genome-Wide Scans under Incomplete Linkage Disequilibrium
Gang Zheng, Jungnam Joo, Dmitri Zaykin +2
Under complete linkage disequilibrium (LD), robust tests often have greater power than Pearson's chi-square test and trend tests for the analysis of case-control genetic associatio…
On a generalized false discovery rate
Sanat K. Sarkar, Wenge Guo
The concept of -FWER has received much attention lately as an appropriate error rate for multiple testing when one seeks to control at least false rejections, for some fixed…
Statistical inference under order restrictions on both rows and columns of a matrix, with an application in toxicology
Eric Teoh, Abraham Nyska, Uri Wormser +1
We present a general methodology for performing statistical inference on the components of a real-valued matrix parameter for which rows and columns are subject to order restrictio…