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8 papers · 1 filter
Representation Transfer for Differentially Private Drug Sensitivity Prediction
Teppo Niinimäki, Mikko Heikkilä, Antti Honkela +1
Motivation: Human genomic datasets often contain sensitive information that limits use and sharing of the data. In particular, simple anonymisation strategies fail to provide suffi…
Probabilistic Model to Treat Flexibility in Molecular Contacts
Riku Hakulinen, Santeri Puranen
Evaluating accessible conformational space is computationally expensive and thermal motions are partly neglected in computer models of molecular interactions. This produces error i…
Analysis of differential splicing suggests different modes of short-term splicing regulation
Hande Topa, Antti Honkela
Motivation: Alternative splicing is an important mechanism in which the regions of pre-mRNAs are differentially joined in order to form different transcript isoforms. Alternative s…
Fast and accurate approximate inference of transcript expression from RNA-seq data
James Hensman, Panagiotis Papastamoulis, Peter Glaus +2
Motivation: Assigning RNA-seq reads to their transcript of origin is a fundamental task in transcript expression estimation. Where ambiguities in assignments exist due to transcrip…
Toward computational cumulative biology by combining models of biological datasets
Ali Faisal, Jaakko Peltonen, Elisabeth Georgii +2
A main challenge of data-driven sciences is how to make maximal use of the progressively expanding databases of experimental datasets in order to keep research cumulative. We intro…
Stronger findings from mass spectral data through multi-peak modeling
Tommi Suvitaival, Simon Rogers, Samuel Kaski
Mass spectrometry-based metabolomic analysis depends upon the identification of spectral peaks by their mass and retention time. Statistical analysis that follows the identificatio…