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10 papers · 1 filter
Closed ecosystems extract energy through self-organized nutrient cycles
Akshit Goyal, Avi I. Flamholz, Alexander P. Petroff +1
Our planet is roughly closed to matter, but open to energy input from the sun. However, to harness this energy, organisms must transform matter from one chemical (redox) state to a…
Statistically-based methodology for revealing real contagion trends and correcting delay-induced errors in the assessment of COVID-19 pandemic
Sebastián Contreras, Juan Pablo Biron-Lattes, H. Andrés Villavicencio +3
COVID-19 pandemic has reshaped our world in a timescale much shorter than what we can understand. Particularities of SARS-CoV-2, such as its persistence in surfaces and the lack of…
Resonant Activation of Population Extinctions
Christopher Spalding, Charles R. Doering, Glenn R. Flierl
Understanding the mechanisms governing population extinctions is of key importance to many problems in ecology and evolution. Stochastic factors are known to play a central role in…
Neutral genetic drift can aid functional protein evolution
Jesse D Bloom, Philip A Romero, Zhongyi Lu +1
BACKGROUND: Many of the mutations accumulated by naturally evolving proteins are neutral in the sense that they do not significantly alter a protein's ability to perform its primar…
Evolution favors protein mutational robustness in sufficiently large populations
Jesse D. Bloom, Zhongyi Lu, David Chen +3
BACKGROUND: An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influenc…
Thermodynamics of Neutral Protein Evolution
Jesse D Bloom, Alpan Raval, Claus O Wilke
Naturally evolving proteins gradually accumulate mutations while continuing to fold to thermodynamically stable native structures. This process of neutral protein evolution is an i…