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10 papers · 2 filters
Positive HBs antigen in the absence of hepatitis B virus infection
José Bras Cachinho, Maud François, Karl Stefic +1
French recommendations for the screening of hepatitis B virus (HBV) infection were updated in 2019 with the association of three markers: HBs Ag, anti-HBs Ab and anti-HBc Ab. These…
How to orient cells in micro-cavities for high resolution imaging of cytokinesis and lumen formation
Alka Bhat, Linjie Lu, Chen-Ho Wang +4
Imaging dynamics of cellular morphogenesis with high spatial-temporal resolution in 3D is challenging, due to the low spatial resolution along the optical axis and photo-toxicity.…
A minimum set of stable blocks for rational design of polypeptide chains Running head: A set of stable blocks for protein rational design
Alexei Nekrasov, Ludmila Alekseeva, Rudolf A. Pogosyan +4
The aim of this work was to find a minimal set of structurally stable pentapeptides, which allows forming a polypeptide chain of a required 3D structure. To search for factors that…
Investigation of the impact of PTMs on the protein backbone conformation
Pierrick Craveur, Tarun Narwani, Joseph Rebehmed +1
Post-Translational Modifications (PTMs) are known to play a critical role in the regulation of the protein functions. Their impact on protein structures, and their link to disorder…
In silico prediction of protein flexibility with local structure approach
Tarun Narwani, Catherine Etchebest, Pierrick Craveur +6
Flexibility is an intrinsic essential feature of protein structures, directly linked to their functions. To this day, most of the prediction methods use the crystallographic data (…
Random-effects meta-analysis of phase I dose-finding studies using stochastic process priors
Moreno Ursino, Christian Röver, Sarah Zohar +1
Phase I dose-finding studies aim at identifying the maximal tolerated dose (MTD). It is not uncommon that several dose-finding studies are conducted, although often with some varia…