output
20132025
most citedAncient human genomes suggest three ancestral populations for present-day Europeans

1.5k citations

9 papers

cond-mat.soft2025★ 6 cited

Sol-gel transition in heteroassociative RNA-protein solutions: A quantitative comparison of coarse-grained simulations and the Semenov-Rubinstein theory

Xinxiang Chen, Jude Ann Vishnu, Pol Besenius +2

Protein RNA-binding domains selectively interact with specific RNA sites, a key interaction that determines the emergent cooperative behaviors in RNA-protein mixtures. Through mole…

q-bio.MN2021★ 8 cited

Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF- signaling

Niklas Kolbe, Lorenz Hexemer, Lukas-Malte Bammert +3

Cells sense their surrounding by employing intracellular signaling pathways that transmit hormonal signals from the cell membrane to the nucleus. TGF-/SMAD signaling encodes var…

q-bio.PE2020★ 10 cited

Mathematical and Computer Modeling of COVID-19 Transmission Dynamics in Bulgaria by Time-depended Inverse SEIR Model

Svetozar Margenov, Nedyu Popivanov, Iva Ugrinova +2

In this paper we explore a time-depended SEIR model, in which the dynamics of the infection in four groups from a selected target group (population), divided according to the infec…

q-bio.BM2020★ 329 cited

The FRET-based structural dynamics challenge -- community contributions to consistent and open science practices

Eitan Lerner, Benjamin Ambrose, Anders Barth +23

Single-molecule Förster resonance energy transfer (smFRET) has become a mainstream technique for probing biomolecular structural dynamics. The rapid and wide adoption of the techni…

q-bio.QM2017★ 550 cited

Precision and accuracy of single-molecule FRET measurements - a worldwide benchmark study

Björn Hellenkamp, Sonja Schmid, Olga Doroshenko +50

Single-molecule Förster resonance energy transfer (smFRET) is increasingly being used to determine distances, structures, and dynamics of biomolecules in vitro and in vivo. However…

q-bio.GN2015★ 110 cited

Genome-wide modelling of transcription kinetics reveals patterns of RNA production delays

Antti Honkela, Jaakko Peltonen, Hande Topa +7

Genes with similar transcriptional activation kinetics can display very different temporal mRNA profiles due to differences in transcription time, degradation rate and RNA processi…

math.NA2014★ 3 cited

Numerical study of cancer cell invasion dynamics using adaptive mesh refinement: the urokinase model

Niklas Kolbe, Jana Katuchova, Nikolaos Sfakianakis +2

In the present work we investigate the chemotactically and proteolytically driven tissue invasion by cancer cells. The model employed is a system of advection-reaction-diffusion eq…

q-bio.PE2013★ 1.5k cited

Ancient human genomes suggest three ancestral populations for present-day Europeans

Iosif Lazaridis, Nick Patterson, Alissa Mittnik +117

We sequenced genomes from a 7,000 year old early farmer from Stuttgart in Germany, an 8,000 year old hunter-gatherer from Luxembourg, and seven 8,000 year old hun…

q-bio.QM2013

Inference of RNA Polymerase II Transcription Dynamics from Chromatin Immunoprecipitation Time Course Data

Ciira wa Maina, Antti Honkela, Filomena Matarese +5

Gene transcription mediated by RNA polymerase II (pol-II) is a key step in gene expression. The dynamics of pol-II moving along the transcribed region influence the rate and timing…