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q-bio.NC2023

Differential action of TIGIT on islet and peripheral nerve autoimmunity in the NOD mouse

Chantal Bécourt, Sandrine Luce, Ute C Rogner +1

We previously demonstrated that the abrogation of the ICOS pathway prevents type 1 diabetes development in the Non Obese Diabetic (NOD) mouse, but results in a CD4+ T-cell dependen…