120 citations
4 papers
sscMap: An extensible Java application for connecting small-molecule drugs using gene-expression signatures
Shu-Dong Zhang, Timothy W. Gant
Background: Connectivity mapping is a process to recognize novel pharmacological and toxicological properties in small molecules by comparing their gene expression signatures with…
A simple and robust method for connecting small-molecule drugs using gene-expression signatures
Shu-Dong Zhang, Timothy W. Gant
Interaction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Using a suitably robust algorithm these…
Effect of pooling samples on the efficiency of comparative studies using microarrays
Shu-Dong Zhang, Timothy W. Gant
Many biomedical experiments are carried out by pooling individual biological samples. However, pooling samples can potentially hide biological variance and give false confidence co…
A statistical framework for the design of microarray experiments and effective detection of differential gene expression
Shu-Dong Zhang, Timothy W. Gant
Four reasons why you might wish to read this paper: 1. We have devised a new statistical T test to determine differentially expressed genes (DEG) in the context of microarray exper…