output
20192022
most citedDynamic nuclear structure emerges from chromatin crosslinks and motors

41 citations

11 papers

cond-mat.soft2022★ 2 cited

Rigidity transitions in zero-temperature polygons

M. C. Gandikota, Amanda Parker, J. M. Schwarz

We study geometrical clues of a rigidity transition due to the emergence of a system-spanning state of self stress in under-constrained systems of individual polygons and spring ne…

cond-mat.soft2021

Thermal Fluctuations of Singular Bar-Joint Mechanisms

Manu Mannattil, J. M. Schwarz, Christian D. Santangelo

A bar-joint mechanism is a deformable assembly of freely rotating joints connected by stiff bars. Here we develop a formalism to study the equilibration of common bar-joint mechani…

cond-mat.soft2021★ 4 cited

Propagating irreversibility fronts in cyclically-sheared suspensions

Jikai Wang, J. M. Schwarz, Joseph D. Paulsen

The interface separating a liquid from its vapor phase is diffuse: the composition varies continuously from one phase to the other over a finite length. Recent experiments on dynam…

cond-mat.soft2021★ 5 cited

Large-scale cortex-core structure formation in brain organoids

Ahmad Borzou, J. M. Schwarz

Brain organoids recapitulate a number of brain properties, including neuronal diversity. However, do they recapitulate brain structure? Using a hydrodynamic description for cell nu…

physics.bio-ph2021

The role of vimentin-nuclear interactions in persistent cell motility through confined spaces

Sarthak Gupta, Alison E. Patteson, J. M. Schwarz

The ability of cells to move through small spaces depends on the mechanical properties of the cellular cytoskeleton and on nuclear deformability. In mammalian cells, the cytoskelet…

cond-mat.soft2021★ 1 cited

A Data-Driven Statistical Description for the Hydrodynamics of Active Matter

Ahmad Borzou, Alison E. Patteson, J. M. Schwarz

Modeling living systems at the collective scale can be very challenging because the individual constituents can themselves be complex and the respective interactions between the co…

cond-mat.soft2021★ 3 cited

Geometric signatures of tissue surface tension in a three-dimensional model of confluent tissue

Preeti Sahu, J. M. Schwarz, M. Lisa Manning

In dense biological tissues, cell types performing different roles remain segregated by maintaining sharp interfaces. To better understand the mechanisms for such sharp compartment…

cond-mat.soft2021★ 8 cited

Buckling without bending morphogenesis: Nonlinearities, spatial confinement, and branching hierarchies

M. C. Gandikota, J. M. Schwarz

During morphogenesis, a featureless convex cerebellum develops folds. As it does so, the cortex thickness is thinnest at the crest (gyri) and thickest at the trough (sulci) of the…

q-bio.SC2020★ 41 cited

Dynamic nuclear structure emerges from chromatin crosslinks and motors

Kuang Liu, Alison E. Patteson, Edward J. Banigan +1

The cell nucleus houses the chromosomes, which are linked to a soft shell of lamin filaments. Experiments indicate that correlated chromosome dynamics and nuclear shape fluctuation…

cond-mat.soft2020★ 29 cited

Sponge-like rigid structures in frictional granular packings

Kuang Liu, Jonathan E. Kollmer, Karen E. Daniels +2

We show how rigidity emerges in experiments of sheared frictional granular materials by using generalizations of two methods for identifying rigid structures. Both approaches, the…

physics.bio-ph2019★ 27 cited

Loops versus lines and the compression stiffening of cells

M. C. Gandikota, Katarzyna Pogoda, Anne van Oosten +4

Both animal and plant tissue exhibit a nonlinear rheological phenomenon known as compression stiffening, or an increase in moduli with increasing uniaxial compressive strain. Does…