output
20092025
most citedNecessary and sufficient conditions for Pareto efficiency in robust multiobjective optimization

72 citations

18 papers

physics.med-ph2025★ 2 cited

Partitioning of multiple brain metastases improves dose gradients in single-isocenter radiosurgery

Johan Sundström, Anton Finnson, Elin Hynning +2

Background: A growing number of cancer patients with brain metastases can benefit from stereotactic radiosurgery (SRS) thanks to recent advances in systemic therapies. With an incr…

physics.med-ph2025★ 7 cited

Shoot-through layers in upright proton arcs unlock advantages in plan quality and range verification

Erik Engwall, Victor Mikhalev, Johan Sundström +2

Background: Upright proton therapy with compact delivery systems has the potential to reduce costs for treatments but could also lead to broadening of the beam penumbra due to ener…

physics.med-ph2023★ 11 cited

Efficient proton arc optimization and delivery through energy layer pre-selection and post-filtering

S. Wuyckens, V. Wase, O. Marthin +7

Proton arc therapy (PAT) has emerged as a promising approach for improving dose distribution, but also enabling simpler and faster treatment delivery in comparison to conventional…

physics.med-ph2022★ 4 cited

Implications of Clinical Target Distribution Weighted Radiotherapy Optimization

Ivar Bengtsson, Anders Forsgren, Albin Fredriksson

Delineating and planning with respect to regions suspected to contain microscopic tumor cells is an inherently uncertain task in radiotherapy. The recently proposed \textit{clinica…

cs.MS2022★ 2 cited

Distributed Objective Function Evaluation for Optimization of Radiation Therapy Treatment Plans

Felix Liu, Måns I. Andersson, Albin Fredriksson +1

The modern workflow for radiation therapy treatment planning involves mathematical optimization to determine optimal treatment machine parameters for each patient case. The optimiz…

physics.med-ph2021★ 27 cited

Robust automated radiation therapy treatment planning using scenario-specific dose prediction and robust dose mimicking

Oskar Eriksson, Tianfang Zhang

Purpose: We present a framework for robust automated treatment planning using machine learning, comprising scenario-specific dose prediction and robust dose mimicking. Methods: The…

physics.med-ph2021★ 11 cited

Probabilistic Pareto plan generation for semiautomated multicriteria radiation therapy treatment planning

Tianfang Zhang, Rasmus Bokrantz, Jimmy Olsson

Objective: We propose a semiautomatic pipeline for radiation therapy treatment planning, combining ideas from machine learning-automated planning and multicriteria optimization (MC…

physics.med-ph2021★ 4 cited

Direct optimization of dose-volume histogram metrics in radiation therapy treatment planning

Tianfang Zhang, Rasmus Bokrantz, Jimmy Olsson

We present a method of directly optimizing on deviations in clinical goal values in radiation therapy treatment planning. Using a new mathematical framework in which metrics derive…

physics.med-ph2021★ 15 cited

Probabilistic feature extraction, dose statistic prediction and dose mimicking for automated radiation therapy treatment planning

Tianfang Zhang, Rasmus Bokrantz, Jimmy Olsson

Purpose: We propose a general framework for quantifying predictive uncertainties of dose-related quantities and leveraging this information in a dose mimicking problem in the conte…

physics.med-ph2020★ 15 cited

Probabilistic dose prediction using mixture density networks for automated radiation therapy treatment planning

Viktor Nilsson, Hanna Gruselius, Tianfang Zhang +2

We demonstrate the application of mixture density networks (MDNs) in the context of automated radiation therapy treatment planning. It is shown that an MDN can produce good predict…

physics.med-ph2019★ 3 cited

On Adaptation Cost and Tractability in Robust Adaptive Radiation Therapy Optimization

Michelle Böck

A framework for online robust adaptive radiation therapy (ART) is presented. This framework is designed to (i) handle interfractional geometric variations following a probability d…

physics.med-ph2018★ 5 cited

On the Interplay between Robustness and Dynamic Planning for Adaptive Radiation Therapy

Michelle Böck, Kjell Eriksson, Anders Forsgren

Interfractional geometric uncertainties can lead to deviations of the actual delivered dose from the prescribed dose distribution. To better handle these uncertainties during treat…

math.OC2018★ 1 cited

Increased accuracy of planning tools for optimization of dynamic multileaf collimator delivery of radiotherapy through reformulated objective functions

Lovisa Engberg, Kjell Eriksson, Anders Forsgren

The purpose of this study is to examine in a clinical setting a novel formulation of objective functions for intensity-modulated radiotherapy treatment plan multicriteria optimizat…

math.OC2016★ 11 cited

Towards Robust Adaptive Radiation Therapy Strategies

Michelle Böck, Anders Forsgren, Kjell Eriksson +1

The authors propose robust adaptive strategies based on stochastic minimax optimization for a series of simulated treatments on a one-dimensional patient phantom. The plan applied…

physics.med-ph2016

Explicit optimization of plan quality measures in intensity-modulated radiation therapy treatment planning

Lovisa Engberg, Kjell Eriksson, Anders Forsgren +1

Conventional planning objectives in optimization of intensity-modulated radiotherapy treatment (IMRT) plans are designed to minimize the violation of dose-volume histogram (DVH) th…

physics.med-ph2015★ 22 cited

The scenario-based generalization of radiation therapy margins

Albin Fredriksson, Rasmus Bokrantz

We give a scenario-based treatment plan optimization formulation that is equivalent to planning with geometric margins if the scenario doses are calculated using the static dose cl…

math.OC2013★ 72 cited

Necessary and sufficient conditions for Pareto efficiency in robust multiobjective optimization

Rasmus Bokrantz, Albin Fredriksson

We provide necessary and sufficient conditions for robust efficiency (in the sense of Ehrgott et al. (2014)) to multiobjective optimization problems that depend on uncertain parame…

nucl-ex2009★ 5 cited

Piezonuclear reactions - do they exist?

G. Ericsson, S. Pomp, H. Sjöstrand +1

In a number of recent articles in this journal F. Cardone and collaborators have claimed the observation of several striking nuclear phenomena which they attribute to "piezonuclear…