443 citations
- National Institutes of HealthUS7 papers
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- Johns Hopkins UniversityUS4 papers
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5 papers · 1 filter
Relative dielectric constants and selectivity ratios in open ionic channels
Bob Eisenberg, Weishi Liu
We investigate the effects of the relative dielectric coefficient on ionic flows in open ion channels, using mathematical analysis of reasonably general Poisson-Nernst-Planck type…
Channels as Enzymes: Oxymoron and Tautology
Bob Eisenberg
Channels are Catalysts for Diffusion and in that sense are Enzymes. This idea is useful for the design and interpretation of experiments.
From Structure to Function in Open Ionic Channels
Bob Eisenberg
We consider a simple working hypothesis that all permeation properties of open ionic channels can be predicted by understanding electrodiffusion in fixed structures, without invoki…
Atomic Biology, Electrostatics, and Ionic Channels
R. S. Eisenberg
I believe an atomic biology is needed to supplement present day molecular biology, if we are to design and understand proteins, as well as define, make, and use them. Topics in the…
Ions in Fluctuating Channels: Transistors Alive
Bob Eisenberg
Ion channels are proteins with a hole down the middle embedded in cell membranes. Membranes form insulating structures and the channels through them allow and control the movement…