output
20122024
most citedDeep EHR: A Survey of Recent Advances in Deep Learning Techniques for Electronic Health Record (EHR) Analysis

1.7k citations

34 papers

cs.CY2024★ 10 cited

Environment Scan of Generative AI Infrastructure for Clinical and Translational Science

Betina Idnay, Zihan Xu, William G. Adams +54

This study reports a comprehensive environmental scan of the generative AI (GenAI) infrastructure in the national network for clinical and translational science across 36 instituti…

physics.bio-ph2024

Exploring the Thermostability of CRISPR Cas12b using Molecular Dynamics Simulations

Yinhao Jia, Katelynn Horvath, Santosh R. Rananaware +2

CRISPR (clustered regularly interspaced short palindromic repeat)- based diagnostics are at the forefront of rapid detection platforms of infectious diseases. The integration of re…

cs.CL2024★ 1 cited

Automatic Summarization of Doctor-Patient Encounter Dialogues Using Large Language Model through Prompt Tuning

Mengxian Lyu, Cheng Peng, Xiaohan Li +3

Automatic text summarization (ATS) is an emerging technology to assist clinicians in providing continuous and coordinated care. This study presents an approach to summarize doctor-…

cs.CL2023★ 71 cited

Model Tuning or Prompt Tuning? A Study of Large Language Models for Clinical Concept and Relation Extraction

Cheng Peng, Xi Yang, Kaleb E Smith +4

Objective To develop soft prompt-based learning algorithms for large language models (LLMs), examine the shape of prompts, prompt-tuning using frozen/unfrozen LLMs, transfer learni…

cs.CL2023★ 400 cited

A Study of Generative Large Language Model for Medical Research and Healthcare

Cheng Peng, Xi Yang, Aokun Chen +16

There is enormous enthusiasm and concerns in using large language models (LLMs) in healthcare, yet current assumptions are all based on general-purpose LLMs such as ChatGPT. This s…

cs.CV2023★ 78 cited

MicroSegNet: A Deep Learning Approach for Prostate Segmentation on Micro-Ultrasound Images

Hongxu Jiang, Muhammad Imran, Preethika Muralidharan +12

Micro-ultrasound (micro-US) is a novel 29-MHz ultrasound technique that provides 3-4 times higher resolution than traditional ultrasound, potentially enabling low-cost, accurate di…

cs.CL2023★ 30 cited

Clinical Concept and Relation Extraction Using Prompt-based Machine Reading Comprehension

Cheng Peng, Xi Yang, Zehao Yu +3

Objective: To develop a natural language processing system that solves both clinical concept extraction and relation extraction in a unified prompt-based machine reading comprehens…

cs.CL2023★ 40 cited

Contextualized Medication Information Extraction Using Transformer-based Deep Learning Architectures

Aokun Chen, Zehao Yu, Xi Yang +3

Objective: To develop a natural language processing (NLP) system to extract medications and contextual information that help understand drug changes. This project is part of the 20…

cs.CL2022★ 33 cited

SODA: A Natural Language Processing Package to Extract Social Determinants of Health for Cancer Studies

Zehao Yu, Xi Yang, Chong Dang +12

Objective: We aim to develop an open-source natural language processing (NLP) package, SODA (i.e., SOcial DeterminAnts), with pre-trained transformer models to extract social deter…

cs.CL2021★ 38 cited

A Study of Social and Behavioral Determinants of Health in Lung Cancer Patients Using Transformers-based Natural Language Processing Models

Zehao Yu, Xi Yang, Chong Dang +8

Social and behavioral determinants of health (SBDoH) have important roles in shaping people's health. In clinical research studies, especially comparative effectiveness studies, fa…

q-bio.PE2021★ 27 cited

Age-Stratified COVID-19 Spread Analysis and Vaccination: A Multitype Random Network Approach

Xianhao Chen, Guangyu Zhu, Lan Zhang +3

The risk for severe illness and mortality from COVID-19 significantly increases with age. As a result, age-stratified modeling for COVID-19 dynamics is the key to study how to redu…

stat.AP2021★ 2 cited

A Simulation Study Evaluating Phase I Clinical Trial Designs for Combinational Agents

Shu Wang, Ji-Hyun Lee

Nowadays, more and more clinical trials choose combinational agents as the intervention to achieve better therapeutic responses. However, dose-finding for combinational agents is m…

eess.SP2020★ 6 cited

Joint Distribution and Transitions of Pain and Activity in Critically Ill Patients

Florenc Demrozi, Graziano Pravadelli, Patrick J Tighe +2

Pain and physical function are both essential indices of recovery in critically ill patients in the Intensive Care Units (ICU). Simultaneous monitoring of pain intensity and patien…

cs.LG2019★ 67 cited

Federated Learning for Healthcare Informatics

Jie Xu, Benjamin S. Glicksberg, Chang Su +3

With the rapid development of computer software and hardware technologies, more and more healthcare data are becoming readily available from clinical institutions, patients, insura…

stat.AP2019★ 1 cited

IFAA: Robust association identification and Inference For Absolute Abundance in microbiome analyses

Zhigang Li, Lu Tian, A. James O'Malley +8

The target of inference in microbiome analyses is usually relative abundance (RA) because RA in a sample (e.g., stool) can be considered as an approximation of RA in an entire ecos…

q-bio.QM2019★ 10 cited

Identifying Cancer Patients at Risk for Heart Failure Using Machine Learning Methods

Xi Yang, Yan Gong, Nida Waheed +4

Cardiotoxicity related to cancer therapies has become a serious issue, diminishing cancer treatment outcomes and quality of life. Early detection of cancer patients at risk for car…

eess.IV2019★ 115 cited

Augmenting the Pathology Lab: An Intelligent Whole Slide Image Classification System for the Real World

Julianna D. Ianni, Rajath E. Soans, Sivaramakrishnan Sankarapandian +9

Standard of care diagnostic procedure for suspected skin cancer is microscopic examination of hematoxylin \& eosin stained tissue by a pathologist. Areas of high inter-pathologist…

cs.CY2019★ 3 cited

Understanding Perceptions and Attitudes in Breast Cancer Discussions on Twitter

Francois Modave, Yunpeng Zhao, Janice Krieger +5

Among American women, the rate of breast cancer is only second to lung cancer. An estimated 12.4% women will develop breast cancer over the course of their lifetime. The widespread…

cs.LG2019★ 7 cited

Enhancing Prediction Models for One-Year Mortality in Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome

Seyedeh Neelufar Payrovnaziri, Laura A. Barrett, Daniel Bis +2

Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need mor…

q-bio.OT2019★ 690 cited

Mapping the Human Body at Cellular Resolution -- The NIH Common Fund Human BioMolecular Atlas Program

Michael P Snyder, Shin Lin, Amanda Posgai +22

Transformative technologies are enabling the construction of three dimensional (3D) maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years,…

cs.LG2018★ 3 cited

Building Computational Models to Predict One-Year Mortality in ICU Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome

Laura A. Barrett, Seyedeh Neelufar Payrovnaziri, Jiang Bian +1

Heart disease remains the leading cause of death in the United States. Compared with risk assessment guidelines that require manual calculation of scores, machine learning-based pr…

stat.ME2018

Learning Gene Regulatory Networks with High-Dimensional Heterogeneous Data

Bochao Jia, Faming Liang

The Gaussian graphical model is a widely used tool for learning gene regulatory networks with high-dimensional gene expression data. Most existing methods for Gaussian graphical mo…

cs.HC2018★ 135 cited

Comparing Clinical Judgment with MySurgeryRisk Algorithm for Preoperative Risk Assessment: A Pilot Study

Meghan Brennan, Sahil Puri, Tezcan Ozrazgat-Baslanti +6

Background: Major postoperative complications are associated with increased short and long-term mortality, increased healthcare cost, and adverse long-term consequences. The large…

stat.ML2018★ 7 cited

Joint Estimation and Inference for Data Integration Problems based on Multiple Multi-layered Gaussian Graphical Models

Subhabrata Majumdar, George Michailidis

The rapid development of high-throughput technologies has enabled the generation of data from biological or disease processes that span multiple layers, like genomic, proteomic or…