14 citations
3 papers
stat.CO2024★ 1 cited
Potential outcome simulation for efficient head-to-head comparison of adaptive dose-finding designs
Michael Sweeting, Daniel Slade, Dan Jackson +1
Dose-finding trials are a key component of the drug development process and rely on a statistical design to help inform dosing decisions. Triallists wishing to choose a design requ…
q-bio.QM2021★ 14 cited
A Knowledge Graph-Enhanced Tensor Factorisation Model for Discovering Drug Targets
Cheng Ye, Rowan Swiers, Stephen Bonner +1
The drug discovery and development process is a long and expensive one, costing over 1 billion USD on average per drug and taking 10-15 years. To reduce the high levels of attritio…
stat.ME2016
Missing binary outcomes under covariate dependent missingness in cluster randomised trials
Anower Hossain, Karla Diaz-Ordaz, Jonathan W. Bartlett
Missing outcomes are a commonly occurring problem for cluster randomised trials, which can lead to biased and inefficient inference if ignored or handled inappropriately. Two appro…