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14 papers · 1 filter
Identification of deregulated transcription factors involved in subtypes of cancers
Magali Champion, Julien Chiquet, Pierre Neuvial +3
We propose a methodology for the identification of transcription factors involved in the deregulation of genes in tumoral cells. This strategy is based on the inference of a refere…
Large scale evaluation of differences between network-based and pairwise sequence-alignment-based methods of dendrogram reconstruction
Daniel Gamermann, Arnau Montagud, J. Alberto Conejero +2
Dendrograms are a way to represent evolutionary relationships between organisms. Nowadays, these are inferred based on the comparison of genes or protein sequences by taking into a…
A model for the integration of conflicting exogenous and endogenous signals by dendritic cells
Quentin Marcou, Irit Carmi-Levy, Coline Trichot +3
Cells of the immune system are confronted with opposing pro- and anti-inflammatory signals. Dendritic cells (DC) integrate these cues to make informed decisions whether to initiate…
Precision of readout at the hunchback gene: analyzing short transcription time traces in living fly embryos
Jonathan Desponds, Huy Tran, Teresa Ferraro +7
The simultaneous expression of the hunchback gene in the numerous nuclei of the developing fly embryo gives us a unique opportunity to study how transcription is regulated in livin…
Predicting genetic interactions from Boolean models of biological networks
Laurence Calzone, Emmanuel Barillot, Andrei Zinovyev
Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.…
Model composition through model reduction: a combined model of CD95 and NF-κB signaling pathways
Elena Kutumova, Andrei Zinovyev, Ruslan Sharipov +1
We propose a new approach to model composition, based on reducing several models to the same level of complexity and subsequent combining them together. Firstly, we suggest a set o…