68 citations
- Johns Hopkins MedicineUS2 papers
- Johns Hopkins UniversityUS2 papers
- National Institute on AgingUS2 papers
- National Institutes of HealthUS2 papers
- Rush University Medical CenterUS2 papers
- Tel Aviv Sourasky Medical CenterIL2 papers
- Tel Aviv UniversityIL2 papers
- University of KansasUS2 papers
- AbbVie (United States)US1 paper
- Massachusetts Institute of TechnologyUS1 paper
- Merck & Co., Inc., Rahway, NJ, USA (United States)US1 paper
- Morpho (United States)US1 paper
13 papers
Flexible Seamless 2-in-1 Design with Sample Size Adaptation
Runjia Li, Liwen Wu, Rachael Liu +1
2-in-1 design (Chen et al. 2018) is becoming popular in oncology drug development, with the flexibility of using different endpoints at different decision time. Based on the observ…
The Impact of US Medical Product Regulatory Complexity on Innovation: Preliminary Evidence of Interdependence, Early Acceleration, and Subsequent Inversion
Iraj Daizadeh
Is the complexity of medical product (medicines and medical devices) regulation impacting innovation in the US? If so, how? Here, this question is investigated as follows: Various…
Singular Secular Kuznets-like Period Realized Amid Industrial Transformation in US FDA Medical Devices: A Perspective on Innovation from 1976 to 2020
Iraj Daizadeh
Introduction: Since inception, the United States (US) Food and Drug Administration (FDA) has kept a robust record of regulated medical devices (MDs). Based on these data, can we ga…
Extracting particle size distribution from laser speckle with a physics-enhanced autocorrelation-based estimator (PEACE)
Qihang Zhang, Janaka C. Gamekkanda, Ajinkya Pandit +9
Extracting quantitative information about highly scattering surfaces from an imaging system is challenging because the phase of the scattered light undergoes multiple folds upon pr…
Incorporating Surrogate Information for Adaptive Subgroup Enrichment Design with Sample Size Re-estimation
Liwen Wu, Qing Li, Mengya Liu +1
Adaptive subgroup enrichment design is an efficient design framework that allows accelerated development for investigational treatments while also having flexibility in population…
Scalar on time-by-distribution regression and its application for modelling associations between daily-living physical activity and cognitive functions in Alzheimer's Disease
Rahul Ghosal, Vijay R. Varma, Dmitri Volfson +4
Wearable data is a rich source of information that can provide deeper understanding of links between human behaviours and human health. Existing modelling approaches use wearable d…