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7 papers · 1 filter
Speaker independence of neural vocoders and their effect on parametric resynthesis speech enhancement
Soumi Maiti, Michael I Mandel
Traditional speech enhancement systems produce speech with compromised quality. Here we propose to use the high quality speech generation capability of neural vocoders for better q…
Perturbation Potentials to Overcome Order/Disorder Transitions in Alchemical Binding Free Energy Calculations
Rajat Kumar Pal, Emilio Gallicchio
We investigate the role of order/disorder transitions in alchemical simulations of protein-ligand absolute binding free energies. We show, in the context of a potential of mean for…
Inclusion of Enclosed Hydration Effects in the Binding Free Energy Estimation of Dopamine D3 Receptor Complexes
Rajat Kumar Pal, Steve Ramsey, Satishkumar Gadhiya +5
Confined hydration and conformational flexibility are some of the challenges encountered for the rational design of selective antagonists of G-protein coupled receptors. We present…
Glass Polymorphism in TIP4P/2005 Water: A Description Based on the Potential Energy Landscape Formalism
Philip H. Handle, Francesco Sciortino, Nicolas Giovambattista
The potential energy landscape (PEL) formalism is a statistical mechanical approach to describe supercooled liquids and glasses. Here we use the PEL formalism to study the pressure…
The Generalized Boltzmann Distribution is the Only Distribution in Which the Gibbs-Shannon Entropy Equals the Thermodynamic Entropy
Xiang Gao, Emilio Gallicchio, Adrian E. Roitberg
We show that the generalized Boltzmann distribution is the only distribution for which the Gibbs-Shannon entropy equals the thermodynamic entropy. This result means that the thermo…
Speech denoising by parametric resynthesis
Soumi Maiti, Michael I Mandel
This work proposes the use of clean speech vocoder parameters as the target for a neural network performing speech enhancement. These parameters have been designed for text-to-spee…