output
20102016
most citedAn expanded evaluation of protein function prediction methods shows an improvement in accuracy

457 citations

11 papers

q-bio.QM2016★ 457 cited

An expanded evaluation of protein function prediction methods shows an improvement in accuracy

Yuxiang Jiang, Tal Ronnen Oron, Wyatt T Clark +144

Background: The increasing volume and variety of genotypic and phenotypic data is a major defining characteristic of modern biomedical sciences. At the same time, the limitations i…

q-bio.PE2014★ 11 cited

Y Chromosome of Aisin Gioro, the Imperial House of Qing Dynasty

Shi Yan, Harumasa Tachibana, Lan-Hai Wei +3

House of Aisin Gioro is the imperial family of the last dynasty in Chinese history - Qing Dynasty (1644 - 1911). Aisin Gioro family originated from Jurchen tribes and developed the…

stat.ML2014★ 23 cited

Functional Principal Component Analysis and Randomized Sparse Clustering Algorithm for Medical Image Analysis

Nan Lin, Junhai Jiang, Shicheng Guo +1

Due to advances in sensors, growing large and complex medical image data have the ability to visualize the pathological change in the cellular or even the molecular level or anatom…

q-bio.GN2014★ 139 cited

Assessing Technical Performance in Differential Gene Expression Experiments with External Spike-in RNA Control Ratio Mixtures

Sarah A. Munro, Steve P. Lund, P. Scott Pine +30

There is a critical need for standard approaches to assess, report, and compare the technical performance of genome-scale differential gene expression experiments. We assess techni…

q-bio.NC2014★ 37 cited

A brain-wide association study of DISC1 genetic variants reveals a relationship with the structure and functional connectivity of the precuneus in schizophrenia

Xiaohong Gong, Wenlian Lu, Keith M. Kendrick +7

The Disrupted in Schizophrenia Gene 1 (DISC1) plays a role in both neural signalling and development and is associated with schizophrenia, although its links to altered brain struc…

q-bio.PE2013★ 5 cited

Discovery of Phylogenetic Relevant Y-chromosome Variants in 1000 Genomes Project Data

Chuan-Chao Wang, Hui Li

Current Y chromosome research is limited in the poor resolution of Y chromosome phylogenetic tree. Entirely sequenced Y chromosomes in numerous human individuals have only recently…

q-bio.PE2013★ 1 cited

Natural selection on human Y chromosomes

Chuan-Chao Wang, Li Jin, Hui Li

The paternally inherited Y chromosome has been widely used in population genetic studies to understand relationships among human populations. Our interpretation of Y chromosomal ev…

q-bio.PE2013★ 1 cited

Present Y chromosomes support the Persian ancestry of Sayyid Ajjal Shams al-Din Omar and Eminent Navigator Zheng He

Chuan-Chao Wang, Ling-Xiang Wang, Manfei Zhang +3

Sayyid Ajjal is the ancestor of many Muslims in areas all across China. And one of his descendants is the famous Navigator of Ming Dynasty, Zheng He, who led the largest armada in…

q-bio.PE2013★ 2 cited

Convergence of Y chromosome STR haplotypes from different SNP haplogroups compromises accuracy of haplogroup prediction

Chuan-Chao Wang, Ling-Xiang Wang, Rukesh Shrestha +5

Short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) are two kinds of commonly used markers in Y chromosome studies of forensic and population genetics. There has…

q-bio.PE2013★ 160 cited

Y Chromosomes of 40% Chinese Are Descendants of Three Neolithic Super-grandfathers

Shi Yan, Chuan-Chao Wang, Hong-Xiang Zheng +13

Demographic change of human populations is one of the central questions for delving into the past of human beings. To identify major population expansions related to male lineages,…

q-bio.QM2010★ 147 cited

CO-phylum: An Assembly-Free Phylogenomic Approach for Close Related Organisms

Huiguang Yi

Phylogenomic approaches developed thus far are either too time-consuming or lack a solid evolutionary basis. Moreover, no phylogenomic approach is capable of constructing a tree di…