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44 papers · 1 filter
A Semiparametric Quantile Single-Index Model for Zero-Inflated Outcomes
Zirui Wang, Tianying Wang
We consider the complex data modeling problem motivated by the zero-inflated and overdispersed data from microbiome studies. Analyzing how microbiome abundance is associated with h…
ZIKQ: An innovative centile chart method for utilizing natural history data in rare disease clinical development
Tianying Wang, Wenfei Zhang, Ying Wei
Utilizing natural history data as external control plays an important role in the clinical development of rare diseases, since placebo groups in double-blind randomization trials m…
Penalized Distributed Lag Interaction Model: Air Pollution, Birth Weight and Neighborhood Vulnerability
Danielle Demateis, Kayleigh P. Keller, David Rojas-Rueda +2
Maternal exposure to air pollution during pregnancy has a substantial public health impact. Epidemiological evidence supports an association between maternal exposure to air pollut…
Semiparametric Estimation of the Shape of the Limiting Bivariate Point Cloud
Reetam Majumder, Benjamin A. Shaby, Brian J. Reich +1
We propose a model to flexibly estimate joint tail properties by exploiting the convergence of an appropriately scaled point cloud onto a compact limit set. Characteristics of the…
Modeling Extremal Streamflow using Deep Learning Approximations and a Flexible Spatial Process
Reetam Majumder, Brian J. Reich, Benjamin A. Shaby
Quantifying changes in the probability and magnitude of extreme flooding events is key to mitigating their impacts. While hydrodynamic data are inherently spatially dependent, trad…
On Bayesian Sequential Clinical Trial Designs
Tianjian Zhou, Yuan Ji
Clinical trials usually involve sequential patient entry. When designing a clinical trial, it is often desirable to include a provision for interim analyses of accumulating data wi…