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- Delft University of TechnologyNL35 papers
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7 papers · 1 filter
Causal effect of chemotherapy received dose intensity on survival outcome: a retrospective study in osteosarcoma
Marta Spreafico, Francesca Ieva, Marta Fiocco
This study aims to analyse the effects of reducing Received Dose Intensity (RDI) in chemotherapy treatment for osteosarcoma patients on their survival by using a novel approach. In…
CGR-CUSUM: A Continuous time Generalized Rapid Response Cumulative Sum chart
Daniel Gomon, Hein Putter, Rob G. H. H. Nelissen +1
Rapidly detecting problems in the quality of care is of utmost importance for the well-being of patients. Without proper inspection schemes, such problems can go undetected for yea…
Longitudinal Latent Overall Toxicity (LOTox) profiles in osteosarcoma: a new taxonomy based on latent Markov models
Marta Spreafico, Francesca Ieva, Marta Fiocco
Due to the presence of multiple types of adverse events with different levels of severity, the analysis of longitudinal toxicity data is a difficult task in cancer studies. In this…
Development, validation and clinical usefulness of a prognostic model for relapse in relapsing-remitting multiple sclerosis
Konstantina Chalkou, Ewout Steyerberg, Patrick Bossuyt +7
Prognosis on the occurrence of relapses in individuals with Relapsing-Remitting Multiple Sclerosis (RRMS), the most common subtype of Multiple Sclerosis (MS), could support individ…
The population-attributable fraction for time-dependent exposures using dynamic prediction and landmarking
Maja von Cube, Martin Schumacher, Hein Putter +3
The public health impact of a harmful exposure can be quantified by the population-attributable fraction (PAF). The PAF describes the attributable risk due to an exposure and is of…
Secondary Phenotype Analysis in Ascertained Family Designs: Application to the Leiden Longevity Study
Renaud Tissier, Roula Tsonaka, Simon P. Mooijaart +2
The case-control design is often used to test associations between the case-control status and genetic variants. In addition to this primary phenotype a number of additional traits…