123 citations
- King's College LondonGB5 papers
- Parc Sanitari Sant Joan de DéuES5 papers
- South London and Maudsley NHS Foundation TrustGB5 papers
- University College LondonGB5 papers
- Centro de Investigación Biomédica en Red de Salud MentalES4 papers
- KU LeuvenBE4 papers
- LAB University of Applied SciencesFI4 papers
- Universitat de BarcelonaES4 papers
- Health Data Research UKGB3 papers
- Lundbeck (Denmark)DK3 papers
- National Health ServiceGB3 papers
- Northwestern UniversityUS3 papers
5 papers · 1 filter
Designing an exploratory phase 2b platform trial in NASH with correlated, co-primary binary endpoints
Elias Laurin Meyer, Peter Mesenbrink, Nicholas A. Di Prospero +5
Non-alcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD) and a disease with high unmet medical need. Platform trials provide great b…
The Relationship between Major Depression Symptom Severity and Sleep Collected Using a Wristband Wearable Device: Multi-centre Longitudinal Observational Study
Yuezhou Zhang, Amos A Folarin, Shaoxiong Sun +19
Research in mental health has implicated sleep pathologies with depression. However, the gold standard for sleep assessment, polysomnography, is not suitable for long-term, continu…
Logistic regression models for patient-level prediction based on massive observational data: Do we need all data?
Luis H. John, Jan A. Kors, Jenna M. Reps +2
Objective: Provide guidance on sample size considerations for developing predictive models by empirically establishing the adequate sample size, which balances the competing object…
A systematic approach to improving the reliability and scale of evidence from health care data
Martijn J. Schuemie, Patrick B. Ryan, George Hripcsak +2
Concerns over reproducibility in science extend to research using existing healthcare data; many observational studies investigating the same topic produce conflicting results, eve…
Incorporating external information in analyses of clinical trials with binary outcomes
Minge Xie, Regina Y. Liu, C. V. Damaraju +1
External information, such as prior information or expert opinions, can play an important role in the design, analysis and interpretation of clinical trials. However, little attent…