Publications (11)
Non-trivial Resource Amount Requirement in the Early Stage for Containing Fatal Diseases
Xiaolong Chen, Tianshou Zhou, Ling Feng +4
During an epidemic control, the containment of the disease is usually achieved through increasing devoted resource to shorten the duration of infectiousness. However, the impact of…
Meta-analysis and Topological Perturbation in Interactomic Network for Anti-opioid Addiction Drug Repurposing
Chunhuan Zhang, Sean Cottrell, Benjamin Jones +5
The ongoing opioid crisis highlights the urgent need for novel therapeutic strategies that can be rapidly deployed. This study presents a novel approach to identify potential repur…
Synchronization and clustering of synthetic genetic networks: A role for cis-regulatory modules
Jiajun Zhang, Zhanjiang Yuan, Tianshou Zhou
The effect of signal integration through cis-regulatory modules (CRMs) on synchronization and clustering of populations of two-component genetic oscillators coupled by quorum sensi…
Hopf Bifurcation in Mean Field Explains Critical Avalanches in Excitation-Inhibition Balanced Neuronal Networks: A Mechanism for Multiscale Variability
Junhao Liang, Tianshou Zhou, Changsong Zhou
Cortical neural circuits display highly irregular spiking in individual neurons but variably sized collective firing, oscillations and critical avalanches at the population level,…
Proteomic Learning of Gamma-Aminobutyric Acid (GABA) Receptor-Mediated Anesthesia
Jian Jiang, Long Chen, Yueying Zhu +5
Anesthetics are crucial in surgical procedures and therapeutic interventions, but they come with side effects and varying levels of effectiveness, calling for novel anesthetic agen…
Machine Learning Study of the Extended Drug-target Interaction Network informed by Pain Related Voltage-Gated Sodium Channels
Long Chen, Jian Jiang, Bozheng Dou +6
Pain is a significant global health issue, and the current treatment options for pain management have limitations in terms of effectiveness, side effects, and potential for addicti…