Publications (9)
SARS-CoV-2 (COVID-19) by the numbers
Yinon M. Bar-On, Avi I. Flamholz, Rob Phillips +1
The current SARS-CoV-2 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about…
The protein cost of metabolic fluxes: prediction from enzymatic rate laws and cost minimization
Elad Noor, Avi Flamholz, Arren Bar-Even +3
Bacterial growth depends crucially on metabolic fluxes, which are limited by the cell's capacity to maintain metabolic enzymes. The necessary enzyme amount per unit flux is a major…
Coarse-Graining and Self-Dissimilarity of Complex Networks
Shalev Itzkovitz, Reuven Levitt, Nadav Kashtan +3
Can complex engineered and biological networks be coarse-grained into smaller and more understandable versions in which each node represents an entire pattern in the original netwo…
Quantitative clarification of key questions about COVID-19 epidemiology
Yinon M. Bar-On, Ron Sender, Avi I. Flamholz +2
Modeling the spread of COVID-19 is crucial for informing public health policy. All models for COVID-19 epidemiology rely on parameters describing the dynamics of the infection proc…
Cross-species analysis traces adaptation of Rubisco towards optimality in a low dimensional landscape
Yonatan Savir, Elad Noor, Ron Milo +1
Rubisco, probably the most abundant protein in the biosphere, performs an essential part in the process of carbon fixation through photosynthesis thus facilitating life on earth. D…
A quantitative compendium of COVID-19 epidemiology
Yinon M. Bar-On, Ron Sender, Avi I. Flamholz +2
Accurate numbers are needed to understand and predict viral dynamics. Curation of high-quality literature values for the infectious period duration or household secondary attack ra…
The Anthropocene by the Numbers: A Quantitative Snapshot of Humanity's Influence on the Planet
Griffin Chure, Rachel A. Banks, Avi I. Flamholz +6
The presence and action of humans on Earth has exerted a strong influence on the evolution of the planet over the past 10,000 years, the consequences of which are now bec…
Understanding the Dynamics and Optimizing the Performance of Chemostat Selection Experiments
Aryeh Wides, Ron Milo
A chemostat enables long-term, continuous, exponential-phase growth in an environment limited as prescribed by the researcher. It is thus a potent tool for laboratory evolution - s…
The Energetic Cost of Building a Virus
Gita Mahmoudabadi, Ron Milo, Rob Phillips
Viruses are incapable of autonomous energy production. Although many experimental studies make it clear that viruses are parasitic entities that hijack the host's molecular resourc…