Publications (4)
Genome organization: experiments and modelling
N. Gilbert, D. Marenduzzo
This is an introduction to the special issue Genome organization: experiments and simulations, published in Chromosome Research, volume 25, issue 1 (2017).
Towards a living earth simulator
M. Paolucci, D. Kossman, R. Conte +17
The Living Earth Simulator (LES) is one of the core components of the FuturICT architecture. It will work as a federation of methods, tools, techniques and facilities supporting al…
Modelling the 3D spatiotemporal organisation of chromatin replication
G. Forte, S. Buonomo, P. R. Cook +3
We propose a polymer model for the dynamics of chromatin replication in three dimensional space. Our simulations indicate that both immobile and tracking replisomes may self-assemb…
A stochastic model of supercoiling-dependent transcription
C. A. Brackley, J. Johnson, A. Bentivoglio +4
We propose a stochastic model for gene transcription coupled to DNA supercoiling, where we incorporate the experimental observation that polymerases create supercoiling as they unw…