Publications (14)
Cystic Lung Phantom to Validate Clinical CT Protocols
Shefra Shah, Farah Hussaini, Dumitru Mazilu +2
In CT-based evaluation of the extent of cystic changes in the lungs of patients with cystic lung diseases, such as Lymphangioleiomyomatosis (LAM), there is a lack of a lung phantom…
Broadband Neutron Interferometer
Dmitry A. Pushin, Dusan Sarenac, Dan Hussey +10
We demonstrate a two phase-grating, multi-beam neutron interferometer by using a modified Ronchi setup in a far-field regime. The functionality of the interferometer is based on th…
Demonstration of a white beam far-field neutron interferometer for spatially resolved small angle neutron scattering
Daniel S. Hussey, Houxun Miao, Guangcui Yuan +6
We provide the first demonstration that a neutron far-field interferometer can be employed to measure the microstructure of a sample. The interferometer is based on the moiré patt…
Spherical-Wave Far-Field Interferometer for Hard X-Ray Phase Contrast Imaging
Houxun Miao, Andrew A. Gomella, Katherine J. Harmon +5
Low dose, high contrast x-ray imaging is of general interest in medical diagnostic applications. X-ray Mach-Zehnder interferometers using collimated synchrotron beams demonstrate t…
DIA-CLIP: a universal representation learning framework for zero-shot DIA proteomics
Yucheng Liao, Han Wen, Weinan E +1
Data-independent acquisition mass spectrometry (DIA-MS) has established itself as a cornerstone of proteomic profiling and large-scale systems biology, offering unparalleled depth…
Multi-color XFEL pulses with variable color separation and time delay for multi-frame diffraction imaging
Xiaodan Liu, Hanxiang Yang, Bingyang Yan +8
X-ray free-electron lasers (XFELs) of high brightness have opened new opportunities for exploring ultrafast dynamical processes in matter, enabling imaging and movies of single mol…
TSA-inspired micro tomosythesis scanner for rapid scouting of histopathology samples
David T. Nguyen, Thomas C. Larsen, Muyang Wang +13
In pathology protocols, each tissue block can generate a large number of sections making it impractical to analyze every section. X-ray microscopy that provides a rapid survey of i…
Online calibration of a linear micro tomosynthesis scanner
Piroz Bahar, David Nguyen, Muyang Wang +3
In a linear tomosynthesis scanner designed for imaging histologic samples of several centimeter size at 10 micrometer resolution, the mechanical instability of the scanning stage (…
Strategic priorities for transformative progress in advancing biology with proteomics and artificial intelligence
Yingying Sun, Jun A, Zhiwei Liu +59
Artificial intelligence (AI) is transforming scientific research, including proteomics. Advances in mass spectrometry (MS)-based proteomics data quality, diversity, and scale, comb…
A Particle-in-Cell Simulation Framework for Thomson Scattering Analysis in Inertial Confinement Fusion
Ziang Zhu, Yifan Liu, Jun Li +11
In inertial confinement fusion (ICF), Thomson scattering (TS) is a widely used diagnostic technique for probing plasma conditions. We present a first-principles numerical approach…
Online geometric calibration of a hybrid CT system for ultrahigh-resolution imaging
Dakota H. King, Eric E. Bennett, Dumitru Mazilu +3
A hybrid imaging system consisting of a standard CT scanner and a low-profile photon-counting detector insert in contact with the patient's body has been used to produce ultrahigh-…
On numerical errors to the fields surrounding a relativistically moving particle in PIC codes
Xinlu Xu, Fei Li, Frank S. Tsung +7
The particle-in-cell (PIC) method is widely used to model the self-consistent interaction between discrete particles and electromagnetic fields. It has been successfully applied to…
Motionless Phase Stepping in X-Ray Phase Contrast Imaging with a Compact Source
Houxun Miao, Lei Chen, Eric E. Bennett +6
X-ray phase contrast imaging offers a way to visualize the internal structures of an object without the need to deposit any radiation, and thereby alleviate the main concern in x-r…
pUniFind: a unified large pre-trained deep learning model pushing the limit of mass spectra interpretation
Jiale Zhao, Pengzhi Mao, Kaifei Wang +12
Deep learning has advanced mass spectrometry data interpretation, yet most models remain feature extractors rather than unified scoring frameworks. We present pUniFind, the first l…