Publications (5)
CrystalBoltz: End-to-End Protein Structure Determination via Experiment-Guided Diffusion for X-Ray Crystallography
Minseo Kim, Huanghao Mai, Jay Shenoy +3
Generative models trained on public databases of protein structures, most of which have been determined by X-ray crystallography, now provide powerful priors for structure predicti…
Amortized Inference for Heterogeneous Reconstruction in Cryo-EM
Axel Levy, Gordon Wetzstein, Julien Martel +2
Cryo-electron microscopy (cryo-EM) is an imaging modality that provides unique insights into the dynamics of proteins and other building blocks of life. The algorithmic challenge o…
Discrete Wavelet Transform for Serial X-ray Crystallography Image Segmentation
Dionisio Doering, Noemie Claret, Guilherme Paulino +10
Upcoming LCLS-II/II-HE operation at repetition rates approaching 1MHz demands on-detector data reduction to manage the resulting data volumes. We present a 2D discrete wavelet tran…
End-to-End Simultaneous Learning of Single-particle Orientation and 3D Map Reconstruction from Cryo-electron Microscopy Data
Youssef S. G. Nashed, Frederic Poitevin, Harshit Gupta +4
Cryogenic electron microscopy (cryo-EM) provides images from different copies of the same biomolecule in arbitrary orientations. Here, we present an end-to-end unsupervised approac…
Deep Generative Modeling for Volume Reconstruction in Cryo-Electron Microscopy
Claire Donnat, Axel Levy, Frederic Poitevin +2
Recent breakthroughs in high-resolution imaging of biomolecules in solution with cryo-electron microscopy (cryo-EM) have unlocked new doors for the reconstruction of molecular volu…