Publications (4)
Challenges of Equitable Vaccine Distribution in the COVID-19 Pandemic
Joseph Bae, Darshan Gandhi, Jil Kothari +25
The COVID-19 pandemic has led to a need for widespread and rapid vaccine development. As several vaccines have recently been approved for human use or are in different stages of de…
Fixation probability of rare nonmutator and evolution of mutation rates
Ananthu James, Kavita Jain
Although mutations drive the evolutionary process, the rates at which the mutations occur are themselves subject to evolutionary forces. Our purpose here is to understand the role…
Fixation probability of a nonmutator in a large population of asexual mutators
Kavita Jain, Ananthu James
In an adapted population of mutators in which most mutations are deleterious, a nonmutator that lowers the mutation rate is under indirect selection and can sweep to fixation. Usin…
Role of epistasis on the fixation probability of a non-mutator in an adapted asexual population
Ananthu James
The mutation rate of a well adapted population is prone to reduction so as to have a lower mutational load. We aim to understand the role of epistatic interactions between the fitn…