Publications (13)
ChromFound: Towards A Universal Foundation Model for Single-Cell Chromatin Accessibility Data
Yifeng Jiao, Yuchen Liu, Yu Zhang +9
The advent of single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) offers an innovative perspective for deciphering regulatory mechanisms by assembl…
Project and Generate: Divergence-Free Neural Operators for Incompressible Flows
Xigui Li, Hongwei Zhang, Ruoxi Jiang +6
Learning-based models for fluid dynamics often operate in unconstrained function spaces, leading to physically inadmissible, unstable simulations. While penalty-based methods offer…
DyneTrion: A Spatio-temporally Coherent Generative Emulator for Protein Dynamics Across Timescales
Kaihui Cheng, Zhiqiang Cai, Peng Tu +6
Proteins function through coordinated motion across multiple spatial and temporal scales, underpinning processes such as ligand binding, allostery, and catalysis. However, accessin…
Tracing the Heart's Pathways: ECG Representation Learning from a Cardiac Conduction Perspective
Tan Pan, Yixuan Sun, Chen Jiang +8
The multi-lead electrocardiogram (ECG) stands as a cornerstone of cardiac diagnosis. Recent strides in electrocardiogram self-supervised learning (eSSL) have brightened prospects f…
Rethinking Intracranial Aneurysm Vessel Segmentation: A Perspective from Computational Fluid Dynamics Applications
Feiyang Xiao, Yichi Zhang, Xigui Li +7
The precise segmentation of intracranial aneurysms and their parent vessels (IA-Vessel) is a critical step for hemodynamic analyses, which mainly depends on computational fluid dyn…
SD-MAD: Sign-Driven Few-shot Multi-Anomaly Detection in Medical Images
Kaiyu Guo, Tan Pan, Chen Jiang +5
Medical anomaly detection (AD) is crucial for early clinical intervention, yet it faces challenges due to limited access to high-quality medical imaging data, caused by privacy con…
Mind the Tool Failures: Achieving Synergistic Tool Gains for Medical Agents
Yunhui Gan, Tan Pan, Kaiyu Guo +5
Medical AI agents increasingly use external tools for diagnosis, treatment recommendation, and evidence retrieval, yet most existing approaches assume that task-appropriate tools a…
Disco: Densely-overlapping Cell Instance Segmentation via Adjacency-aware Collaborative Coloring
Rui Sun, Yiwen Yang, Kaiyu Guo +8
Accurate cell instance segmentation is foundational for digital pathology analysis. Existing methods based on contour detection and distance mapping still face significant challeng…
Dynamic PDB: A New Dataset and a SE(3) Model Extension by Integrating Dynamic Behaviors and Physical Properties in Protein Structures
Ce Liu, Jun Wang, Zhiqiang Cai +10
Despite significant progress in static protein structure collection and prediction, the dynamic behavior of proteins, one of their most vital characteristics, has been largely over…
Beyond Instance-Level Self-Supervision in 3D Multi-Modal Medical Imaging
Tan Pan, Shuhao Mei, Yixuan Sun +8
Self-supervised pre-training methods in medical imaging typically treat each individual as an isolated instance, learning representations through augmentation-based objectives or m…
PET2Rep: Towards Vision-Language Model-Drived Automated Radiology Report Generation for Positron Emission Tomography
Yichi Zhang, Wenbo Zhang, Zehui Ling +12
Positron emission tomography (PET) is a cornerstone of modern oncologic and neurologic imaging, distinguished by its unique ability to illuminate dynamic metabolic processes that t…
Minimal Semantic Sufficiency Meets Unsupervised Domain Generalization
Tan Pan, Kaiyu Guo, Dongli Xu +8
The generalization ability of deep learning has been extensively studied in supervised settings, yet it remains less explored in unsupervised scenarios. Recently, the Unsupervised…
Aneumo: A Large-Scale Multimodal Aneurysm Dataset with Computational Fluid Dynamics Simulations and Deep Learning Benchmarks
Xigui Li, Yuanye Zhou, Feiyang Xiao +16
Intracranial aneurysms (IAs) are serious cerebrovascular lesions found in approximately 5\% of the general population. Their rupture may lead to high mortality. Current methods for…